What is GHRP-2?
GHRP-2 (Growth Hormone Releasing Hexapeptide) is a synthetic ghrelin analogue. Similar to ghrelin, it stimulates the release of endogenous growth hormone in the anterior pituitary. GHRP-2 is extremely synergistic with endogenous GHRH (Growth Hormone releasing-hormone) including synthetic GHRH analogues such as Modified GRF (1-29).
When GHRP-2 is used in conjunction with a GHRH such as Modified GRF (1-29) the GH pulse is amplified, potentially being 3 times stronger than GHRP-2 alone.
Although GHRP-2 is an analogue of ghrelin which has a very important role in hunger, it does not actually increase appetite significantly.
Studies have shown that in humans, a dose of 1mcg per kg of bodyweight (For example a 100mcg dose for a 100kg man) of GHRP-2 and an equal size dose of a GHRH such as Modified GRF (1-29) creates a 3 hour GH pulse that is double the amplitude when compared to 8 IU of synthetic GH.
The neuronal excitation last for an hour after application. This causes a high amplitude pulsation of GH which slowly finds its way back down to baseline after 3 hours. This pulse is very similar to natural GH release. For many purposes this is superior to synthetic GH which circulates for 8 hours and causes cellular desensitization due to the longer lasting shallower pulses.
Due to the synthesis of GHRP-2 being so much simpler and cheaper than creating GH from an e.coli, and being still being so effective, it could eventually replace conventional exogenous GH therapy.