What is GHRP-2?
GHRP-2 (Growth Hormone Releasing Hexapeptide) is a synthetic ghrelin analogue. Similar to ghrelin, it stimulates the release of endogenous growth hormone in the anterior pituitary. GHRP-2 is extremely synergistic with endogenous GHRH (Growth Hormone releasing-hormone) including synthetic GHRH analogues such as Modified GRF (1-29).
When GHRP-2 is used in conjunction with a GHRH such as Modified GRF (1-29) the GH pulse is amplified, potentially being 3 times stronger than GHRP-2 alone.
Although GHRP-2 is an analogue of ghrelin which has a very important role in hunger, it does not actually increase appetite significantly.
Studies have shown that in humans, a dose of 1mcg per kg of bodyweight (For example a 100mcg dose for a 100kg man) of GHRP-2 and an equal size dose of a GHRH such as Modified GRF (1-29) creates a 3 hour GH pulse that is double the amplitude when compared to 8 IU of synthetic GH.
The neuronal excitation last for an hour after application. This causes a high amplitude pulsation of GH which slowly finds its way back down to baseline after 3 hours. This pulse is very similar to natural GH release. For many purposes this is superior to synthetic GH which circulates for 8 hours and causes cellular desensitization due to the longer lasting shallower pulses.
Due to the synthesis of GHRP-2 being so much simpler and cheaper than creating GH from an e.coli, and being still being so effective, it could eventually replace conventional exogenous GH therapy.
There are no reviews yet.