Growth Hormone Releasing Peptide-6 (GHRP-6) is a synthetic hexapeptide, which specifically stimulates secretion of growth hormone by pituitary somatotrophs. Somatotrophs are cells in the anterior pituitary that release pituitary growth hormone .
GHRP-6 is one of many synthetic met-enkephalin analogues that include unnatural D-amino acides and was developed for its growth hormone-releasing activity
GHRP-6 stimulates growth hormone secretion, the increase of growth hormone levels can decrease body fat, increase muscle mass, and increase strength and stamina.
The release of growth hormones stimulated by GHRP-6 signals the liver to secrete an anabolic hormone specifically the Insulin-like Growth Factor (IGF-1), which has also been implicated in improving the body’s ability to burn fat and build muscle.
GHRP-6 is widely used by fitness professionals for pronounced muscle gains and decreased healing and recovery time.
Mechanism of Action
The sequence of GHRP-6, which contains six amino acids, notifies the human brain to release growth hormones from the pituitary gland while obstructing the release of Somatostatin, which is a peptide hormone that regulates the endocrine system. This then signals the liver to secrete an anabolic hormone, the Insulin-like Growth Factor (IGF-1).
GHRP-6 initiates a ghrelin mimetic response, which stimulates the ghrelin receptors of the body. The ghrelin receptors enable the brain to send a signal to the pituitary gland to secrete the growth hormone. The secreted growth hormone then assists the liver to release IGF-1.